23andMe and the human genome


23andMe, Inc. is the leading consumer genetics and research company. Founded in 2006, the mission of the company is to help people access, understand and benefit from the human genome. The company was named by Fortune magazine as a "Company Changing the World," and named one of MIT Technology Review's "50 Smartest Companies." 23andMe has more than 3 million customers worldwide, with ~ 85 percent of customers consented to participate in research. 23andMe, Inc. is located in Mountain View, CA. More information is available at www.23andMe.com.

Genetic lineage

With 23andMe’s genetic ancestry service you can trace your lineage to 31 populations worldwide through your DNA. Our Ancestry Composition report analyzes genetic variants across all chromosomes to provide a breakdown of global ancestry by percentages. The average customer can trace their DNA to at least five different regions from around the world. Customers will also have their 23 pairs of chromosomes “painted” — a color-coded digital sketch unraveling your DNA, detailing the amount, or length, of specific ancestry on each chromosome.

The service also includes DNA Relatives, an optional tool matching you with close or distant relatives based on shared DNA. Ninety-five percent of 23andMe customers participating in DNA Relatives connect with a third degree cousin or closer relative. And for those interested in ancient ancestors, our Neanderthal report tells people how much Neanderthal DNA remains in their genome.

Genetic health information

The 23andMe Health + Ancestry Service includes all of the 23andMe ancestry reports and an additional 65+ reports on genetic risk for certain diseases, carrier status genetic risks you may pass down to offspring, along with daily wellness and reports on physical traits. This is the first and only genetic service available directly to consumers that includes reports that meet FDA requirements for clinical and scientific validity. We analyze, compile and distill the information extracted from ~650,000 points in your genome into reports you can access online.

You can learn about your personal health risk for diseases such as Alzheimer’s, Parkinson’s, hereditary thrombophilia (harmful blood clots) and alpha-1 antitrypsin deficiency, which could lead to lung and liver problems.

We also provide more than 40 reports on your carrier status for certain diseases, like cystic fibrosis or sickle cell anemia. These reports do not tell you your own personal risk for the condition, rather the likelihood you may pass down a harmful genetic variant to your offspring, who may be affected by the disease if your partner is also a carrier.

You can also learn how genetics affect your diet with reports on caffeine consumption, response to saturated fats, genetic predisposition to weigh more or less than average, ability to digest lactose, and more.

Knowing this information can help you make more informed decisions about your health and lifestyle.